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Multi Drug Resistance (MDR) is a disorder that affects the permeability-glycoprotein (P-gp).
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Multi Drug Resistance (MDR) is a disorder that affects the permeability-glycoprotein (P-gp). This is a transmembrane protein encoded by the ABCB1 gene, also called multidrug resistance 1 gene (MDR1). It functions as a pump in the blood-brain barrier (BBB) to prevent potentially toxic compounds/drugs to reach the brain. Without the P-gp protein, compounds/drugs either can reach the brain in excess (intoxication) or can’t reach the brain (drug resistance).
The variant of MDR analysed in this test decreases the effectiveness of phenobarbital (PB) treatment for epilepsy. The variant occurs in the Border Collie, and is caused by an incompletely dominant mutation to the gene ABCB1.
Caractéristiques cliniques
Affected dogs also affected by Idiopathic Epilepsy (IE) are significantly less likely to experience a reduction in seizure frequency when treated with phenobarbital (PB).
Additional Information
Références
Pubmed ID: 21488961
Omia ID: 1402