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A recessive mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
Informations générales
A recessive mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs. The variant analysed in this test, designated as c^1, is found in the Portuguese Water Dog. A related variant, c^2, has been observed in the Bichon Frise, Chesapeake Bay Retriever, Curly-coated Retriever, Irish Terrier, Lagotto Romagnolo and Spanish Water Dog.
Caractéristiques cliniques
Affected dogs have a curly-haired coat instead of wavy haired. Coats must be of sufficient length to curl in the first place.
Dogs carrying the additional mutations for long coat (FGF5) and furnishings (RSPO2) will have furnishings and long soft coats, rather than wiry ones. When dogs carry variants in both FGF5 and KRT71, long and curly coat is seen.
If all three mutations (KRT71, FG5 en RSPO2) are present, the phenotype is long and curly with furnishings.
Additional Information
Références
Pubmed ID: 19713490
Omia ID: 245