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Von Willebrand Disease (vWD) is a group of bleeding disorders caused by deficiency in the von Willebrand factor (vWF), which results in poorly functioning blood platelets and can lead to uncontrolled bleeding.
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Caractéristiques
| Breeds | Barbet, Beauceron, Berger allemand, Berger de Beauce, Bichon havanais, Bouvier Bernois, Caniche miniature, Caniche standard, Cardigan Gallois Corgi, Chien de ferme dano-suédois, Chien de perdrix de Drente ou Epagneul à perdrix de Drente, Cockapoo, Grand Basset Griffon Vendéen, Labradoodle Australien, Manchester Terrier (Standard), Manchester Terrier (Toy), Miniature Dachshund, Pinscher allemand, Poodle (Toy), Schnauzer miniature ou nain, setter irlandais, Stabyhoun, Teckel, Terrier blanc des Highlands de l’Ouest, Terrier Kerry Blue, Australian Cobberdog, Bernedoodle, Coton de Tulear, Doberman, Dutch Shepherd, Kromfohrländer, Papillon, Schipperke, Welsh Corgi Pembroke |
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| Gene | |
| Organ | |
| specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Von Willebrand Disease (vWD) is a group of bleeding disorders caused by deficiency in the von Willebrand factor (vWF), which results in poorly functioning blood platelets and can lead to uncontrolled bleeding. Type I Von Willebrand Disease (vWD I) is found in a wide variety of breeds, including the Doberman, Poodle and Corgi.
The disorder is caused by a recessive mutation to the gene VWF. However, in the Doberman and Kromfohrländer, the disease has been found to inherit in an incomplete dominant manner instead. (That is, dogs of these breeds may sometimes develop the disorder while having only one copy of the mutation.)
Caractéristiques cliniques
The degree of bleeding caused by vWD I can be variable. Affected dogs are more susceptible to extended bleeding from tooth eruptions, minor wounds and surgical procedures. They also may experience nosebleeds, bleeding gums, hematomas, or gastrointestinal bleeding.
Additional Information
Références
Pubmed ID: 23911791, 31131110, 27525650
Omia ID: 1057