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Multi Drug Resistance 1 or Multidrug Sensitivity seems to inherited in an autosomal dominant way with incomplete penetrance.
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Caractéristiques
| Breeds | Berger allemand, Berger américain miniature, Berger australien, Bobtail, Chien de berger des Shetland, Collie à poil court, Collie rugueux, Lévrier whippet, Border Collie |
|---|---|
| Gene | |
| Organ | |
| specimen | Écouvillon, EDTA sanguin, Héparine sanguine, Sperme, Tissu |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Multi Drug Resistance 1 or Multidrug Sensitivity seems to inherited in an autosomal dominant way with incomplete penetrance. Affected dogs are susceptible to neurotoxicity following the administration of certain commonly used drugs like Ivermectin. The condition is linked to the ATP Binding Cassette Subfamily B Member 1 (ABCB1) gene, also known as the multidrug resistance (MDR1) gene. This gene encodes for a drug transporter protein called P-glycoprotein (P-gp), which plays a crucial role in the blood-brain barrier by preventing certain drugs from accumulating in the brain. Dogs with two copies of the MDR1 variant are at higher risk and should be closely monitored to avoid adverse reactions to certain medications. Some dogs with one copy of the MDR1 variant have also been reported to exhibit multidrug sensitivity, though symptoms vary hugely.
Caractéristiques cliniques
La neurotoxicité après l’administration du médicament, qui varie en fonction de la dose, est le signe principal. Les chiens peuvent présenter une ataxie, des tremblements, des convulsions, une salivation excessive, une obtundation, une bradycardie, une mydriase, une perte de menace, une perte de réponses à la lumière papillaire, un coma et un arrêt respiratoire.
Additional Information
This test is based on an association study.
The disorder is noted as incomplete dominant. It means that, in some cases, carriers of the mutation have been observed to present with a milder form of the disorder and in other cases no symptoms were present at all.
Références
Pubmed ID: 11692082
Omia ID: 1402