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Coat colour in dogs is controlled by a wide range of different genes working together.
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Caractéristiques
| Breeds | Bouledogue Français, Chien thaïlandais à crête dorsale, Lévrier arabe, Beagle, Chow Chow, Papillon, Staffordshire Bull Terrier |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Dilution, or D-Locus, corresponds to the gene for melanophilin, MLPH, which is involved in the distribution of pigment. Autosomal recessive mutations of the D-Locus result in a ‘dilution’ of dark coat colours, turning them lighter and more silvery.
Any combination of two mutant alleles will result in a diluted coat. This variant of the D-Locus mutation, designated as d^2, is found in dogs such as the Chow Chow, Sloughi and Thai Ridgeback.
Caractéristiques cliniques
Affected animals (two alleles with mutation; d/d) have diluted coat and nose colour and the eye colour lightens to amber. Black dilutes into grey, also called blue or charcoal. The coat ranges from silver to almost black, but all homozygous dogs have a blue nose. Chocolate/brown/liver dilutes into lilac/light tan/Isabella, whilst their noses vary from pink, liver to isabella. Red/yellow/cream dilutes into champagne. Mutations in the D-locus can sometimes cause colour dilution alopecia, as the dilute coat colour is linked to hair loss (alopecia). The severity and occurrence of alopecia vary both within and between breeds, meaning only some dogs with d/d will develop hair loss and certain breeds are more prone to the condition. The variable presentation of this condition suggests that additional genetic or environmental factors contribute to its development. Affected dogs typically display hair loss between four months and two years of age, and their coats may appear dry and dull.
Additional Information
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.
Additional, undiscovered variants of the D-Locus mutation are likely to exist.
Références
Pubmed ID: 29349785
Omia ID: 31