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Neuroaxonal dystrophy (NAD) in dogs is an inherited condition that affects the nervous system.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Neuroaxonal dystrophy (NAD) in dogs is an inherited condition that affects the nervous system. In the condition, there is swelling of cells in the brain which affect the communication with nerve cells. NAD can be present at birth or develop later in a dog’s life, leading to neurological dysfunction and loss of coordination.
There are multiple variants of mutations known in different breeds. In the Toy Australian Shepherd and Miniature American Shepherd, a variant of the disorder has been observed which is probably caused by a recessive mutation to the gene RNF170.
Caractéristiques cliniques
Affected dogs display slowly progressive neurological signs which can include ataxia (loss of coordination), weakness of the hind limbs, dragging of the toes while walking, seizures, and fearful behaviour.
Additional Information
Références
Pubmed ID: DOI: 10.21203/rs.3.rs-3914204/v1
Omia ID: