€57,48 €47,50 hors TVA
Coat colour in horses is controlled by a wide range of different loci working together.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Hair, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
Informations générales
Coat colour in horses is controlled by a wide range of different loci working together. Modifications that can occur include dilutions of the base coat colour. There are multiple genes known to have this effect and one of them is the solute carrier family 45, member 2 gene (SLC45A2, previously known as MATP). This gene is thought to disrupt the distribution of pigment, which lead to a dilution of coat colour.
There are several known mutations on this gene, of which two are tested here. The first one leads to a Cream dilution (Cr). This Cream dilution mutation influences both red and black pigment and dilutes the basic coat colour to lighter coat shades. The mutation shows incomplete dominance. This means that one copy of the Cr allele produces a dilute colour, and two copies of the Cr allele produces a more extreme dilute colour. Another mutation in the SLC45A2 gene is the Pearl dilution (Prl) or Barlink Factor. This rare autosomal recessive mutation dilutes only red pigments in the coat, mane, tail and skin. Only animals with two copies of this mutation have a lightened coat colour with bright eye colours.
Caractéristiques cliniques
Carriers of the mutant Cr allele have a dilute colour. Depending on the base colour it results in Palomino, Buckskin or Smokey Black. For Smokey Black the effect might be very subtle and not clear to see. Having two mutated Cr alleles (Cr/Cr) results in Cremello, Perlino or Smokey Cream. They are also called “double-dilutes” or “blue-eyed cream”. These animals have pale blue eyes, and the skin is rosy-pink.
Horses with two affected Pearl alleles (homozygous for the Prl) typically display a diluted coat colour, often with a noticeable pale or "frosted" appearance. The dilution lightens the base coat colour that is distinct from the Cream dilution. A bay horse appears to have a golden hue (“Pearl or Frosted Bay”), while a chestnut horse appears to have a creamy shade (“Pearl chestnut”). The eyes, skin around the eyes and muzzles, mane and tail can also show lighter colours.
The Pearl dilution is known to interact with the Cream dilution and can produce phenotypes that are called “pseudo-double cream” (dilute pale skin and blue/green eyes).
Additional Information
This test analyses two mutations in the SLC45A2 gene that are associated with the Cream and Pearl dilutions. Mutations in other dilution genes that may produce coat colours that resemble either cream and/or pearl will not be detected by this test.
Références
Pubmed ID: 12605854, 30968968
Omia ID: 1344