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Polydactyly is a anatomical condition where an animal has more toes that usual.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
Informations générales
Polydactyly is a anatomical condition where an animal has more toes that usual. Polydactyly inherits in an autosomal dominant way. Multiple variants are known, this test focusses on the UK2 variant. Another variant that can be tested, is the UK1 variant or the HW variant (Maine Coon).
All tested variants have a mutation in the ZRS enhancer of the LMBR1 gene. The mutations influence the regulation of the developmental Sonic Hedgehog (SHH) gene. This gene influences the development of limb buds, resulting in polydactyl limbs.
Caractéristiques cliniques
Polydactyly in cats, a birth defect, results in more than 18 digits. Extra toes can appear on any paw, in various combinations, and their occurrence follows an irregular statistical pattern. Polydactyly doesn’t influence the overall health of a cat. It is not painful or harmful and it doesn’t lead to more health issues.
Additional Information
Other polydactyl variants exist but the causal mutations for these variants have not been discovered yet. Therefore they cannot be tested.
Références
Pubmed ID: 18156157
Omia ID: 810