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Pituitary Dwarfism in German Shepherd Dogs is a condition characterized by a combined deficiency of growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin, and gonadotropins.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
Informations générales
Pituitary Dwarfism in German Shepherd Dogs is a condition characterized by a combined deficiency of growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin, and gonadotropins. It is caused by an autosomal recessive mutation in the LIM homeobox 3 (LHX3) gene. Due to this mutation, the pituitary glands of affected dogs fail to develop normally, leading to a deficiency of multiple hormones essential for growth and development. This condition has been observed in German Shepherd Dogs, Czechoslovakian Wolfdogs, and Saarloos Wolfdogs.
Caractéristiques cliniques
Affected dogs are noticeably smaller than their littermates by 2 to 3 months of age, and will never reach full adult size. Other clinical symptoms include retention of secondary hairs (puppy coat) with a concurrent lack of primary or guard hairs, and bilateral symmetrical alopecia. As the disease progresses, severe alopecia becomes apparent. If left untreated, affected dogs often die or are humanely euthanized by five years of age due to a severely diminished quality of life.
Additional Information
Références
Pubmed ID: 22132174
Omia ID: 2314