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Primary Open Angle Glaucoma (POAG) is an eye disorder that builds up pressure in the eye and affects the nerves of the retina, causing pain and damaging vision.
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Caractéristiques
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Écouvillonnage, sanguin EDTA, sanguine hépariné, sperme, tissu |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Informations générales
Primary Open Angle Glaucoma (POAG) is an eye disorder that builds up pressure in the eye and affects the nerves of the retina, causing pain and damaging vision. This variant of the disease, likely caused by a recessive mutation to the gene ADAMTS17, occurs in the Chinese Shar-Pei/Shar Pei/Sharpei. The mutation is also associated in this breed with a similar painful eye condition, Primary Lens Luxation (PLL). Similar variants of POAG also occur in the Basset Hound, Petit Basset Griffon Vendéen, and Basset Fauve de Bretagne.
Caractéristiques cliniques
In affected dogs the fibres which support the lens are broken down or disintegrated. As a result, the lens falls into the wrong position within the eye. This result is a loss of vision.
Additional Information
Dans Shar-Pei chinois, une mutation dans ADAMTS17 s’est avérée pour être associée à un diagnostic de POAG, PLL ou tous les deux. Cependant, il n’est pas encore clair si ces cas sont PLL classique ou représentent un processus de maladie chronique avec POAG comme seule maladie primaire.
Références
Pubmed ID: 29287154
Omia ID: 1976