These are usually illnesses where the gene is located on the sex chromosomes (X-chromosome and Y-chromosome). A female animal has two X-chromosomes, whereas a male animal has only one X-chromosome and one Y-chromosome.

Inheritance for daughters: see other inheritance, either autosomal, recessive or autosomal, dominant.
Below the table for inheritance of male offspring.

 Inheritance X-linked Parents Reproductive cells Offspring Interpretation breeding Interpretation veterinarian
NORMAL SIRE AA and AY A/A X A/Y SONS 100% AY SONS 100% NORMAL SONS 100% HEALTHY
NORMAL DAM x
AFFECTED  SIRE
AA and BY A/A x B/Y SONS 100% AY SONS 100% NORMAL SONS 100% HEALTHY
CARRIER DAM x NORMAL SIRE AB and AY A/B x A/Y SONS
50% AY
50% BY
SONS
50% CARRIER
50% AFFECTED
SONS
50% HEALTHY
50% AFFECTED
CARRIER DAM  x AFFECTED SIRE AB and BY A/B x B/Y SONS
50% AY
50% BY
SONS
50% CARRIER
50% AFFECTED
SONS
50% HEALTHY
50% AFFECTED
AFFECTED DAM x NORMAL SIRE BB and AY B/B x A/Y SONS 100% BY SONS 100% AFFECTED SONS 100% AFFECTED
AFFECTED DAM x NORMAL SIR BB and BY B/B x B/Y SONS 100% BY SONS 100% AFFECTED SONS 100% AFFECTED
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